When viable T-lymphocytes in transfused blood products engraft and multiply in the tissues of a recipient, they can react against the tissues of the recipient; this is called Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD). Irradiation has been the standard to date for reducing the level of contaminating T-Cells to potentially decrease the risk of transfusion TA-GVHD. In addition to irradiation, AABB recognizes that contaminating T-cell activity is also reduced by the psoralen/UVA light treatment method of pathogen reduction, potentially lowering the risk of transfusion-associated graft versus host disease (TA-GVHD). This learning activity will compare these two methodologies for potential reduction of the risk of TA-GVHD.
- Describe the underlying cause and approaches for addressing Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)
- Discuss the AABB Standards for Blood Banks and Transfusion Services (BBTS) that address approaches for lowering the risk of or preventing TA-GVHD.
- Understand the two options authorized by the AABB Standards for prevention of TA-GVHD: irradiation and psoralen/UVA light treatment (pathogen reduction) of platelets.
Level of Instruction
Author / Speaker
Karen Giordano, MS, MT (ASCP) SBB
Karen Giordano is focused on medical education for clinicians on topics around blood safety, transfusion medicine, and provides support for ongoing clinical trials. Karen has a long career in medical affairs and clinical research in transfusion medicine, hemostasis, coagulation, critical care, trauma and hematology. Her educational background includes an MS in biomedical chemistry from Thomas Jefferson University in Philadelphia and a BS in medical technology from Wesley College, as well as licensure as a clinical laboratory scientist and a specialist in blood bank (SBB).
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